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MT1-MMP plays a critical role in hematopiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells.

      

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K
Blood, 119, 5405 (2012)

         
          

Development of a hypoxia-selective near-infrared fluorescence probe for non-invasive tumor imaging.

      

Youssif BG, Okuda K, Kadonosono T, Salem OI, Hayallah AA, Hussein MA, Kizaka-Kondoh S, Nagasawa H
Chem Pharm Bull (Tokyo), 60: 402-407 (2012)

         
          

2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.

      

Okuda K, Okabe Y, Kadonosono T, Ueno T, Youssif BG, Kizaka-Kondoh S, Nagasawa H
Bioconjug Chem, 21: 324-329 (2012)

         
          

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging

      

Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Watanabe H, Tani T, Inoue M, Tsukamoto T, Toyoda T, Tanaka T, Hirota K, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G & Kizaka-Kondoh S
PLoS ONE 6(11):e26640 (2011)

         
          

HIFs活性化細胞のバイオセンシングによる腫瘍内低酸素微小環境の可視化と治療薬開発

      

門之園 哲哉、 近藤 科江
医学のあゆみ, 241(6): 450-455 (2012)